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      L-Arginine

      ProArgi-9 L-Arginine Dietary Supplement

      Benefits of L-Arginine

      • Supports cardiovascular health
      • Enhances blood flow to vital organs
      • Combats the negative effects of premature cardiovascular aging
      • Sweetened with Xylitol to enhance oral health
      • May aid in decreasing body fat
      • Anti-aging benefits
      • Supports healthy sexual performance
      • Maintains healthy blood sugar levels already in normal range
      • May boost energy levels
       

      Benefits of Nitric Oxide and Arginine

       

      22 Reasons to use L-Arginine

      The nitric oxide derived from arginine is directly or indirectly implicated in practically every cellular response and health condition imaginable, from the cardiovascular system to the immune system, and hormone function to nerve function. Although an exhaustive list of possible applications for the amino acid is not included, the following are the primary scientifically backed reasons why anyone - even healthy people - should consider adding the arginine to their health and wellness regimen.

      1. It is one thousand times more powerful than any naturally occurring antioxidant in the body. Arginine`s antioxidant properties support various body systems and may protect against heart disease, stroke, cancer, and diabetes, as well as slowing premature aging. 1, 2
      2. It offers wide-ranging cardiovascular support, including controlling blood pressure 3, 4 and plaque formation. Nitric oxide keeps arteries relaxed and pliable for normal blood pressure, preventing hypertension and angina. 5
      3. It enhances memory,6 particularly long-term memory, and may help to reverse the effects of dementia and Alzheimer's disease.7
      4. It boosts human growth hormone (HGH) production, which has antiaging properties. 8
      5. It enhances communication of messenger cells between nerves and the brain. 9
      6. It may help improve immune function10 and fight bacterial infections. 11
      7. It may help in the treatment and prevention of diabetes since many disease complications, including poor circulation and blindness, are vascular in nature. Arginine is also found to regulate insulin secretion in the pancreas. 12,13
      8. It may inhibit the division and proliferation of cancer cells. 14,15
      9. It helps with cholesterol control by lowering serum and LDL cholesterol levels. 16
      10. It enhances male sexual performance by treating vascular erectile dysfunction (ED). 17
      11. Its anticoagulant abilities reduce clotting to lower heart attack and stroke risk. 18
      12. It reduces pregnancy-related hypertension, a risk factor for both the expecting mother and the unborn child. 19
      13. It is useful in the treatment of asthma by opening pulmonary pathways for easier breathing and the treatment of lung disorders. 20, 21
      14. It relaxes hypertonic sphincter muscles, preventing and healing hemorrhoids.22
      15. It boosts lean muscle mass and preserves bone density by encouraging HGH production,23 which also leads to a reduction in fatty tissue. Because af these properties, it may be useful in weight management and strength training.
      16. It can help offset cardiovascular and lung damage caused by tobacco use,24 since nitric oxide levels in smokers are less than half of those found in nonsmokers.25
      17. It helps to accelerate wound healing26 and postsurgery recovery.27 Research has shown it is useful in treating burn wounds28 and stimulates wound healing in the elderly.29
      18. It may be useful in enhancing athletic performance due to its ability to boost exercise tolerance,30 its beneficial effect on the lungs, and its effect on HGH levels. Which helps with building lean muscle tissue.
      19. It may be used to improve the function of the prostate.31
      20. It may prevent and possible reverse the effects of osteoporosis by positively affecting bone mass.32
      21. It has been used in the treatment of irritable bowel syndrome33 and to reduce the occurrence of ulcers - especially stress- related - without affecting gastric acid production.34, 35
      22. It may improve renal function and slow the progression of renal disease and age-related chronic renal failure.36,37 Arginine`s protective effect on the kidneys may also benefit those with diabetes.


      Scientific Validation / References

      1. KochupurackalP,etal.Nitricoxide:anantioxidantandneuroprotector.Annals of the New York Academy of Sciences. 2002; 962:389-401.
      2. Kumar CA, Das UN. Lipid peroxides, antioxidants and nitric oxide in pa- tients with pre-eclampsia and essential hypertension. Med Sci Monitor. 2000 Sep-Oct; 6(5):901-7.
      3. 18. Brown, M.D., Dengel, D.R., Supiano, M.A. Nitric Oxide Biomarkers are As- sociated with the Blood Pressure-Lowering Effects of Dietary Sodium Restriction in Older Hypertensives. Circulation (Abstract I). 1997; 96:I-539.
      4. Rosano, G.M.C., Tanina, G., Cerquetani, E., Leonardo, F., Pelliccia, F., Bonfigli, B., and Chierchia, F.L. L-arginine Improves Endothelial Function in Newly Diagnosed Hypertensives. The Journal of the American College of Cardiology (Supplement A). 1998; 31:262a
      5. Moncada, F., Palmer, R.M.J., Higgs, E.A. The Discovery of Nitric Oxide as the Endogenous Nitrovasodilator. Hypertension. 1988; 12:365-72.
      6. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory impairment. Med Hypotheses. 1994 Jun; 42(6):363-6.
      7. Tarkowski E, et al. Intrathecal release of nitric oxide in Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord. 2000 Nov-Dec; 11(6):322-6.
      8. Ghigo E, Arvat E, Gianotti L, et al. Hypothalamic growth hormone-insulin-like growth facto-1 axis across the human life span. J Pediatr Endocrinol Metab.2000; 13 Suppl 6:1493-502.
      9. Fried R, Merrell WC. The Arginine Solution. New York, NY. Warner Books, 1999.
      10. Efron D, Barbul A. Role of arginine in immunonutrition. J Gastroentol. 2000; 35 Suppl 12:20-3..
      11. Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE. A randomized double-blind study of oral L-arginine for treatment of interstitial cystitis. J Urol. 1999 Feb; 161(2):558-65.
      12. Piatti PM, Monti LD, Valsecchi G, et al. Long term oral L-arginine admin- istration improves peripheral and hepatic insulin sensitivity in type 2 diabetes. Diabetes Care. 2001 May; 24(5):875-80.
      13. 28. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free Radic Biol Med. 1998 Nov 1; 25(7):757-65.
      14. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colorectal cancer. Br J Surg. 1997 Feb; 84(2):238-41.
      15. Brittenden J, et al. Dietary supplementation with L-arginine in patients with breast cancer (> 4cm.) receiving multi-modality treatment: report of a feasibility study. Br J Cancer. 1994 May; 69(5):918-21.
      16. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega) nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr. 1996 Oct; 126(10):2563-7.
      17. 17.Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int. 1999 Feb; 83(3):269-73.
      18. 33. Wolf A, et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol. 1997 Mar 1; 29(3):479.
      19. Podjarny, E., et al. Pregnancy-induced hypertension in rats with adriamycin nephropathy is associated with inadequate production of nitric oxide. Hypertension. 1997; 29:986-991.
      20. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness to histamine in asthma. Thorax. 1999 Nov; 54(11):1033-5.
      21. De Gouw HW, Marshall-Partridge SJ, et al. Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects. J Appl Physiol. 2001 Feb; 90(2):586-92.
      22. Fried R, Merrell WC. The Arginine Solution. New York, New York. Warner Books, 1999. pp 4-5.
      23. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc. 2000 Dec; 32(12):2102-8.
      24. Heitzer, T., Just, H., and Munzell, T. Antioxidant Vitamin C Improves Endothelium Function in Chronic Smokers. Circulation. 1996; 94:9.
      25. Zeiher, A.M., Schachinger, V., and Minners, J. Long-Term Cigarette Smoking Impairs Endothelium-Dependent Coronary Arterial Vasodilator Function. Circulation. 1995; 92:1094-1100.
      26. Barbul A, et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990 Aug; 108(2):331-6; discussion 336-7.
      27. Braga M, Gianotti L Raedelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg. 1999 Apr; 134(4):428-33.
      28. De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J of Nutri. 1998 May; 128(5):797-803.
      29. Kirk SJ, et al Arginine stimulates wound healing and immune function in elderly humans. Surgery. 1993 Aug; 114(2):155-9; discussion 160.
      30. Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercised induced QT dispersion and exercise tolerance in stable anginapectoris. Int J Cardiol. 2000 Sep 15; 75(2-3): 205-10.
      31. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the change with aging. Prostate. 2001 Jun 15; 48(1):40-6.
      32. Fini M, et al. Effect of l-lysine and L-arginine on primary osteoblast cultures from normal and osteopenic rats. Biomed Pharmacother. 2001 May; 55(4):213-21.
      33. Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses. Methods Find Exp Clin Pharmacol. 2001 Jan-Feb; 23(1):13-7.
      34. Ohta Y, Nishida K., Protective effect of l-arginine against stress-induced gastric mucosal lesions in rats and its relation to nitric acid-mediated inhibition of neutrophil infiltration. Pharmacal Res. 2001 Jun; 43(6):535-41.
      35. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indo- methacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res. 2001 May; 43(5):463-7.
      36. De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of arginine supplementation in chronic renal failure. Kidney Int. 1999 Aug; 56(2):674-84.
      37. Reckelhoff JF, et al. Long-term dietary supplementation with L-arginine prevents age related reduction in renal function. Am J Physiol. 1997 Jun; 272(6 Pt 2):1768-74.

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      San Antonio, TX 78258
      Phone: (210) 985-1700

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