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L-Arginine
Benefits of L-Arginine
Supports cardiovascular health
Enhances blood flow to vital organs
Combats the negative effects of premature cardiovascular aging
Sweetened with Xylitol to enhance oral health
May aid in decreasing body fat
Anti-aging benefits
Supports healthy sexual performance
Maintains healthy blood sugar levels already in normal range
May boost energy levels
Benefits of Nitric Oxide and Arginine
22 Reasons to use L-Arginine
The nitric oxide derived from arginine is directly or indirectly
implicated in practically every cellular response and health condition
imaginable, from the cardiovascular system to the immune system, and
hormone function to nerve function. Although an exhaustive list of
possible applications for the amino acid is not included, the following
are the primary scientifically backed reasons why anyone - even healthy
people - should consider adding the arginine to their health and
longevity regimen.
It is one thousand times more powerful than any naturally occurring
antioxidant in the body. Arginine`s antioxidant properties support
various body systems and may protect against heart disease, stroke,
cancer, and diabetes, as well as slowing premature aging.
1, 2
It offers wide-ranging cardiovascular support, including controlling
blood pressure
3, 4
and plaque formation. Nitric oxide keeps arteries relaxed and
pliable for normal blood pressure, preventing hypertension and
angina.
5
It enhances memory,6 particularly
long-term memory, and may help to reverse the effects of dementia
and Alzheimer's disease.7
It enhances communication of messenger cells between nerves and the
brain.
9
It may help improve immune function10
and fight bacterial infections.
11
It may help in the treatment and prevention of diabetes since many
disease complications, including poor circulation and blindness, are
vascular in nature. Arginine is also found to regulate insulin
secretion in the pancreas. 12,13
It may inhibit the division and proliferation of cancer cells.
14,15
It helps with cholesterol control by lowering serum and LDL
cholesterol levels.
16
It enhances male sexual performance by treating vascular erectile
dysfunction (ED).
17
Its anticoagulant abilities reduce clotting to lower heart attack
and stroke risk.
18
It reduces pregnancy-related hypertension, a risk factor for both
the expecting mother and the unborn child.
19
It is useful in the treatment of asthma by opening pulmonary
pathways for easier breathing and the treatment of lung disorders.
20, 21
It relaxes hypertonic sphincter muscles, preventing and healing
hemorrhoids.22
It boosts lean muscle mass and preserves bone density by encouraging
HGH production,23
which also leads to a reduction in fatty tissue. Because af these
properties, it may be useful in weight management and strength
training.
It can help offset cardiovascular and lung damage caused by tobacco
use,24
since nitric oxide levels in smokers are less than half of those
found in nonsmokers.25
It helps to accelerate wound healing26
and postsurgery recovery.27
Research has shown it is useful in treating burn wounds28
and stimulates wound healing in the elderly.29
It may be useful in enhancing athletic performance due to its
ability to boost exercise tolerance,30
its beneficial effect on the lungs, and its effect on HGH levels.
Which helps with building lean muscle tissue.
It may be used to improve the function of the prostate.31
It may prevent and possible reverse the effects of osteoporosis by
positively affecting bone mass.32
It has been used in the treatment of irritable bowel syndrome33
and to reduce the occurrence of ulcers - especially stress- related
- without affecting gastric acid production.34, 35
It may improve renal function and slow the progression of renal
disease and age-related chronic renal failure.36,37
Arginine`s protective effect on the kidneys may also benefit those
with diabetes.
Scientific Validation / References
KochupurackalP,etal.Nitricoxide:anantioxidantandneuroprotector.Annals
of the New York Academy of Sciences. 2002; 962:389-401.
Kumar CA, Das UN. Lipid peroxides, antioxidants and nitric oxide
in pa- tients with pre-eclampsia and essential hypertension. Med
Sci Monitor. 2000 Sep-Oct; 6(5):901-7.
18. Brown, M.D., Dengel, D.R., Supiano, M.A. Nitric Oxide
Biomarkers are As- sociated with the Blood Pressure-Lowering
Effects of Dietary Sodium Restriction in Older Hypertensives.
Circulation (Abstract I). 1997; 96:I-539.
Rosano, G.M.C., Tanina, G., Cerquetani, E., Leonardo, F.,
Pelliccia, F., Bonfigli, B., and Chierchia, F.L. L-arginine
Improves Endothelial Function in Newly Diagnosed Hypertensives.
The Journal of the American College of Cardiology (Supplement
A). 1998; 31:262a
Moncada, F., Palmer, R.M.J., Higgs, E.A. The Discovery of Nitric
Oxide as the Endogenous Nitrovasodilator. Hypertension. 1988;
12:365-72.
Pautler EL. The possible role and treatment of deficient
microcirculation regulation in age-associated memory impairment.
Med Hypotheses. 1994 Jun; 42(6):363-6.
Tarkowski E, et al. Intrathecal release of nitric oxide in
Alzheimer's disease and vascular dementia. Dement Geriatr
Cogn Disord. 2000 Nov-Dec; 11(6):322-6.
Ghigo E, Arvat E, Gianotti L, et al. Hypothalamic growth
hormone-insulin-like growth facto-1 axis across the human life
span. J Pediatr Endocrinol Metab.2000; 13 Suppl 6:1493-502.
Fried R, Merrell WC. The Arginine Solution. New York, NY. Warner
Books, 1999.
Efron D, Barbul A. Role of arginine in immunonutrition. J
Gastroentol. 2000; 35 Suppl 12:20-3..
Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE. A
randomized double-blind study of oral L-arginine for treatment
of interstitial cystitis. J Urol. 1999 Feb; 161(2):558-65.
Piatti PM, Monti LD, Valsecchi G, et al. Long term oral
L-arginine admin- istration improves peripheral and hepatic
insulin sensitivity in type 2 diabetes. Diabetes Care. 2001 May;
24(5):875-80.
28. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system
on chemical induced diabetes mellitus. Free Radic Biol Med. 1998
Nov 1; 25(7):757-65.
Heys SD, et al. Dietary supplementation with L-arginine:
Modulation of tumor infiltrating lymphocytes in patients with
colorectal cancer. Br J Surg. 1997 Feb; 84(2):238-41.
Brittenden J, et al. Dietary supplementation with L-arginine in
patients with breast cancer (> 4cm.) receiving multi-modality
treatment: report of a feasibility study. Br J Cancer. 1994 May;
69(5):918-21.
Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric
oxide synthase inhibitor, L-N(omega) nitroarginine, elevates
serum triglycerides and cholesterol and lowers hepatic fatty
acid oxidation. J Nutr. 1996 Oct; 126(10):2563-7.
17.Chen J, Wollman Y, Chernichovsky T, et al. Effect of high
dose nitric oxide donor L-arginine in men with organic erectile
dysfunction. BJU Int. 1999 Feb; 83(3):269-73.
33. Wolf A, et al. Dietary L-arginine supplementation normalizes
platelet aggregation in hypercholesterolemic humans. J Am Coll
Cardiol. 1997 Mar 1; 29(3):479.
Podjarny, E., et al. Pregnancy-induced hypertension in rats with
adriamycin nephropathy is associated with inadequate production
of nitric oxide. Hypertension. 1997; 29:986-991.
De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral
L-arginine on airway hyper-responsiveness to histamine in
asthma. Thorax. 1999 Nov; 54(11):1033-5.
De Gouw HW, Marshall-Partridge SJ, et al. Role of nitric oxide
in the airway response to exercise in healthy and asthmatic
subjects. J Appl Physiol. 2001 Feb; 90(2):586-92.
Fried R, Merrell WC. The Arginine Solution. New York, New York.
Warner Books, 1999. pp 4-5.
Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity
dynamic human muscle performance enhanced by a metabolic
intervention. Med Sci Sports Exerc. 2000 Dec; 32(12):2102-8.
Heitzer, T., Just, H., and Munzell, T. Antioxidant Vitamin C
Improves Endothelium Function in Chronic Smokers. Circulation.
1996; 94:9.
Zeiher, A.M., Schachinger, V., and Minners, J. Long-Term
Cigarette Smoking Impairs Endothelium-Dependent Coronary
Arterial Vasodilator Function. Circulation. 1995; 92:1094-1100.
Barbul A, et al. Arginine enhances wound healing and lymphocyte
immune responses in humans. Surgery. 1990 Aug; 108(2):331-6;
discussion 336-7.
Braga M, Gianotti L Raedelli G, et al. Perioperative
immunonutrition in patients undergoing cancer surgery: results
of a randomized double-blind phase 3 trial. Arch Surg. 1999 Apr;
134(4):428-33.
De-Souza DA, Greene LJ. Pharmacological nutrition after burn
injury. J of Nutri. 1998 May; 128(5):797-803.
Kirk SJ, et al Arginine stimulates wound healing and immune
function in elderly humans. Surgery. 1993 Aug; 114(2):155-9;
discussion 160.
Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine
supplementation on exercised induced QT dispersion and exercise
tolerance in stable anginapectoris. Int J Cardiol. 2000 Sep 15;
75(2-3): 205-10.
Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated
relaxation and nitrinergic innervation in the rabbit prostate:
the change with aging. Prostate. 2001 Jun 15; 48(1):40-6.
Fini M, et al. Effect of l-lysine and L-arginine on primary
osteoblast cultures from normal and osteopenic rats. Biomed
Pharmacother. 2001 May; 55(4):213-21.
Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic,
noncholinergic responses of the human colon smooth muscle and
the role of K+channels in these responses. Methods Find Exp Clin
Pharmacol. 2001 Jan-Feb; 23(1):13-7.
Ohta Y, Nishida K., Protective effect of l-arginine against
stress-induced gastric mucosal lesions in rats and its relation
to nitric acid-mediated inhibition of neutrophil infiltration.
Pharmacal Res. 2001 Jun; 43(6):535-41.
Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide
in indo- methacin- induced gastric ulceration by a mechanism
independent of gastric acid secretion. Pharmacol Res. 2001 May;
43(5):463-7.
De Nicola L, Bellizzi V, Minutolo R, et al. Randomized,
double-blind, placebo controlled study of arginine
supplementation in chronic renal failure. Kidney Int. 1999 Aug;
56(2):674-84.
Reckelhoff JF, et al. Long-term dietary supplementation with
L-arginine prevents age related reduction in renal function. Am
J Physiol. 1997 Jun; 272(6 Pt 2):1768-74.
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